Psoriasis
Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin.[6] These skin patches are typically red, dry, itchy, and scaly.[3] On people with darker skin the patches may be purple in colour.[9] Psoriasis varies in severity from small, localized patches to complete body coverage.[3] Injury to the skin can trigger psoriatic skin changes at that spot, which is known as the Koebner phenomenon.[10]
There are five main types of psoriasis: plaque, guttate, inverse, pustular, and erythrodermic.[6] Plaque psoriasis, also known as psoriasis vulgaris, makes up about 90 percent of cases.[4] It typically presents as red patches with white scales on top.[4] Areas of the body most commonly affected are the back of the forearms, shins, navel area, and scalp.[4] Guttate psoriasis has drop-shaped lesions.[6] Pustular psoriasis presents as small non-infectious pus-filled blisters.[11] Inverse psoriasis forms red patches in skin folds.[6] Erythrodermic psoriasis occurs when the rash becomes very widespread, and can develop from any of the other types.[4]Fingernails and toenails are affected in most people with psoriasis at some point in time.[4] This may include pits in the nails or changes in nail color.[4]
Psoriasis is generally thought to be a genetic disease that is triggered by environmental factors.[3] In twin studies, identical twins are three times more likely to be affected compared to non-identical twins. This suggests that genetic factors predispose to psoriasis.[4] Symptoms often worsen during winter and with certain medications, such as beta blockers or NSAIDs.[4] Infections and psychological stress can also play a role.[3][6]Psoriasis is not contagious.[4] The underlying mechanism involves the immune system reacting to skin cells.[4] Diagnosis is typically based on the signs and symptoms.[4]
There is no cure for psoriasis; however, various treatments can help control the symptoms.[4] These treatments include steroid creams, vitamin D3 cream, ultraviolet light and immune system suppressing medications, such as methotrexate.[6] About 75 percent of cases can be managed with creams alone.[4] The disease affects two to four percent of the population.[8] Men and women are affected with equal frequency.[6] The disease may begin at any age, but typically starts in adulthood.[5] Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, Crohn’s disease and depression.[4] Psoriatic arthritis affects up to 30 percent of individuals with psoriasis.[11]
Huntingdon
Huntingdon is a borough in (and the county seat of) Huntingdon County, Pennsylvania, United States. It is located along the Juniata River, approximately 32 miles (51 km) east of Altoona and 98 miles (158 km) west of Harrisburg. It is the largest population center near Raystown Lake, a winding, 28 miles (45 km) long flood-control reservoir managed by the U. S. Army Corps of Engineers. The borough is located on the main line of the Norfolk Southern (formerly Pennsylvania) Railroad, in an agricultural and outdoor recreational region with extensive forests and scattered deposits of ganister rock, coal, fire clay, and limestone. Historically, the region surrounding Huntingdon was dotted with iron furnaces and forges, consuming limestone, iron ore and wood (for charcoal production) throughout the 19th century. Dairy farms dominate the local agriculture. The town is a regular stop for the Amtrak passenger service which connects Harrisburg with Pittsburgh.
Huntingdon is home to Juniata College, a private liberal arts college founded by members of the Church of the Brethren in 1876, and branch campuses of DuBois Business College and Penn Highlands Community College. In adjoining Smithfield Township (across the Juniata River) are the regional headquarters of the Pennsylvania Game Commission (Southcentral Division) and the Bureau of Forestry (Rothrock State Forest). State Game Lands 322 extends north from Huntingdon Borough in the direction of Petersburg. Public parks are the George N. Weaver Memorial Park (ball field and playground) at the end of 16th Street, Portstown Park along the Juniata River, and Blair Field bordering Standing Stone Creek. Historic Blair Park, directly across the same stream, is owned and managed by a nonprofit group; it contains a gazebo, and a level hiking and biking trail. A vintage chapel within the park is used by the congregation of Epiphany of Our Lord Orthodox Church.